Ajaxian picked up on new travel site Vayama.com which focuses on finding the best fares and schedules for international flights. It has a very cool interface and uses a combination of Ajax and Flex to provide a pretty slick interface. It looks like Flex is primarily used to display an interactive map to show the actual travel route and once you pull up fares, you can actually display multiple routes on the Flex map. Pretty cool!
There's still some quirks that need to be cleaned up such as saving the inputted travel info if you go to another page (oddly, the Flex map retains this when you move to another page).
Overall, its a nicely designed site which seems leverage the best of Ajax & Flex functionality.