AJAX is definite hot when it comes to the web but it takes some know-how to navigate Cascading Style Sheets, DHTML, the DOM, JSON and all of the other things that go into the whole Web 2.0 experience
Adobe has jumped onto the AJAX bandwagon by releasing a new AJAX framework called Spry along with several demos that show how to use it.
I'm not sure how it compares to script.aculo.us or prototype but if they build hooks into CFML that make it even easier to build RIAs, they'll have me sold.